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Surface enhanced resonance Raman (SERS) is a powerful optical technique, which can help enhance the sensitivity of Raman spectroscopy aided by noble metal nanoparticles (NPs). However, current SERS‐NPs are often suboptimal, which can aggregate under physiological conditions with much reduced SERS enhancement. Herein, a robust one‐pot method has been developed to synthesize SERS‐NPs with more uniform core diameters of 50 nm, which is applicable to both non‐resonant and resonant Raman dyes. The resulting SERS‐NPs are colloidally stable and bright, enabling NP detection with low‐femtomolar sensitivity. An algorithm has been established, which can accurately unmix multiple types of SERS‐NPs enabling potential multiplex detection. Furthermore, a new liposome‐based approach has been developed to install a targeting carbohydrate ligand, i.e., hyaluronan, onto the SERS‐NPs bestowing significantly enhanced binding affinity to its biological receptor CD44 overexpressed on tumor cell surface. The liposomal hyaluronan (HA)‐SERS‐NPs enabled visualization of spontaneously developed breast cancer in mice in real time guiding complete surgical removal of the tumor, highlighting the translational potential of these new glyco‐SERS‐NPs. 

Magnetic flux densities ( B-fields) and field intensities ( H-fields) in thin films are investigated from the viewpoints of Berry phase and topological Hall effect. The well-known origin of the topological Hall effect is an emergent B-field originating from the Berry phase of conduction electrons, but Maxwell’s equations predict the relevant perpendicular component B z to be zero. This paradox is solved by treating the electrons as point-like objects in Lorentz cavities. These cavities can also be used to interpret magnetization measurements in the present and other contexts, but structural and magnetic inhomogeneities lead to major modifications of the Lorentz-hole picture.